Topic: Newcastle University eTheses: The roles of FOXP3 and CXCR4.

Results from this study are consistent with FOXP3 functioning as an important tumour suppressor in breast cancer. Indeed, the functions of FOXP3 in breast epithelium can now potentially be extended to include influencing the expression of CXCR4 and response to the pro-metastatic chemokine, CXCL12.

1 Re: Foxp3 thesis

FOXP3 AND CTLA-4: HOW ISOFORMS REGULATE IMMUNOLOGICAL. Foxp3δ2δ7 mice phenocopied Foxp3 deficient scrufy mice and died from severe autoimmune disorder starting from 3 weeks of age. The Foxp3δ2δ7 mouse may provide a useful alternative for studying FOXP3 isoform function in Treg cells in vivo. In paper III we investigated the role of CTLA-4 in Treg cell-mediated suppression on DCs.

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2 Re: Foxp3 thesis

Expression of FoxP3, IL17, IL33, and IL35 in Oral Lichen. Cite this item: Javvadi, L. R. (2014). Expression of FoxP3, IL17, IL33, and IL35 in Oral Lichen Planus (Thesis, Doctor of Clinical Dentistry).

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3 Re: Foxp3 thesis

Natural occurring regulatory T cells: role of. in manipulating FOXP3 function and/or using CD4+CD25+FOXP3+ Treg cells as cell therapy to modify immune responses in cancer, autoimmunity and transplantation. The transcription factor FOXP3 has been shown to regulate negatively some genes such as Il2 and positively others, such as Cd25 and Ctla4.

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4 Re: Foxp3 thesis

Number and function of CD4 CD25 FoxP3 regulatory T cells. Number and function of CD4+CD25+FoxP3+ regulatory T cells in patients suffering from multiple sclerosis Inaugural-Dissertation zur Erlangung des Doktorgrades

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5 Re: Foxp3 thesis

The Role of Autophagy in Regulatory T Cell Function and. A Thesis Submitted to the Faculty of .. even proceeds Foxp3 transcriptome contributed by signaling from T cell receptor (TCR), IL2R - and TGF- βR.

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6 Re: Foxp3 thesis

THE EFFECT OF CHEMOKINES ON T REGULATORY CELLS FOLLOWING. FOXP3 78 2.11.5. It is an honour for me to thank those who made this thesis possible. First and foremost, I owe my deepest gratitude to my supervisor,.

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7 Re: Foxp3 thesis

CD8+FoxP3+ T cells: A new player in the immune response to. CD8+FoxP3+ T cells: A new player in the immune response to ovarian cancer by Sara E.F. Kost B.Sc., University of Manitoba, 2011 A Thesis Submitted in.

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